6 Min Read
What Medications Should You Not Take with Magnesium?

Magnesium is a crucial mineral that supports many bodily functions, but what medications should you not take with magnesium?
While magnesium has numerous health benefits, it can interact with certain medications, affecting their absorption or causing side effects.
In this article, we'll explore the medications that can interfere with magnesium, why these interactions happen, and how to safely use magnesium with other medication.
What this article covers:
- Introduction to Magnesium and Its Uses
- Medications That Should Not Be Taken with Magnesium
- Medications That Interfere with Magnesium Absorption
- Medications That Can Cause Dangerous Side Effects When Combined with Magnesium
- How to Safely Take Magnesium with Other Medications
Introduction to Magnesium and Its Uses
What is Magnesium?
Magnesium is an essential mineral that plays a role in over 300 biochemical reactions in the body. It supports muscle and nerve function, bone health, and energy production.
Magnesium is naturally found in foods such as leafy greens, nuts, and whole grains, but many people choose to supplement their intake to ensure they meet their daily requirements.
It's essential for regulating blood sugar, maintaining heart health, and contributing to overall wellness.
Why Is Magnesium Important for Health?
Magnesium is necessary for many processes in the body. It helps maintain normal muscle and nerve function, supports a healthy immune system, and regulates blood pressure.
It also plays a role in bone health by supporting calcium metabolism.
Many individuals use magnesium supplements to address deficiencies or to support specific health needs, such as relieving muscle cramps, improving sleep, or managing stress.
Common Uses of Magnesium Supplements
Magnesium supplements are commonly used to treat magnesium deficiency, alleviate muscle cramps, support heart health, and manage stress.
Magnesium is also often used to relieve constipation due to its natural laxative properties.
Athletes use magnesium to help with recovery, while others take it to improve sleep quality. Magnesium can also help with reducing symptoms of anxiety and migraines.

Medications That Should Not Be Taken with Magnesium
Overview of Magnesium-Drug Interactions
Magnesium can interact with certain medications, leading to reduced absorption or potential side effects. Some medications can lower magnesium levels in the body, while others can interfere with how the body absorbs magnesium.
Understanding these interactions is key to ensuring that you get the most benefit from both magnesium and your medications.
Why Some Medications Interact with Magnesium
Some medications interact with magnesium because they either affect how magnesium is absorbed or how it's excreted.
For example, magnesium can bind to certain drugs in the digestive system, preventing them from being fully absorbed.
Additionally, medications that impact kidney function can alter magnesium levels, as magnesium is primarily excreted through the kidneys.
This can lead to either an increase or decrease in magnesium levels in the body.
Medications That Interfere with Magnesium Absorption
Antibiotics and Magnesium
Certain antibiotics, especially tetracycline and quinolone antibiotics, can interact with magnesium. When taken together, magnesium can bind to these antibiotics in the gut, reducing their absorption and effectiveness.
To avoid this, it's recommended to take antibiotics at least 2 hours apart from magnesium supplements. This ensures that the antibiotic can be fully absorbed and work effectively.
Diuretics and Magnesium
Diuretics, commonly known as "water pills," are often prescribed to manage high blood pressure and swelling.
Some diuretics, such as loop diuretics (e.g., furosemide), can increase the excretion of magnesium through urine, leading to lower magnesium levels in the body.
On the other hand, potassium-sparing diuretics (e.g., spironolactone) may raise magnesium levels. If you take diuretics, it's important to monitor magnesium levels, as prolonged use can lead to magnesium deficiency.
Proton Pump Inhibitors (PPIs) and Magnesium
Proton pump inhibitors (PPIs), like pantoprazole and omeprazole, are commonly used to treat acid reflux and ulcers by reducing stomach acid.
Long-term use of PPIs can impair magnesium absorption, leading to magnesium deficiency. Low magnesium levels can result in symptoms such as muscle cramps, weakness, and heart irregularities.
If you are using PPIs, it's important to discuss magnesium supplementation with your healthcare provider.
Bisphosphonates and Magnesium
Bisphosphonates, such as alendronate and risedronate, are used to treat osteoporosis by preventing bone loss.
These medications can interfere with magnesium absorption. It's best to take magnesium supplements at least 2 hours apart from bisphosphonates to avoid any interference with the absorption of both the medication and the mineral.

Medications That Can Cause Dangerous Side Effects When Combined with Magnesium
Magnesium and Blood Pressure Medications
Magnesium supplements can interact with certain blood pressure medications, such as calcium channel blockers and ACE inhibitors.
When combined with magnesium, these medications can lower blood pressure too much, leading to dizziness, fainting, or even shock in extreme cases.
If you are on blood pressure medication, it's important to consult your healthcare provider about the timing and dosage of magnesium to avoid potential interactions.
Magnesium and Heart Medications
Magnesium is involved in maintaining a normal heart rhythm, and taking it with heart medications, such as digoxin, can increase the risk of arrhythmias.
Magnesium can enhance the effects of heart medications, potentially leading to dangerous side effects.
Always consult a healthcare professional before combining magnesium with heart medications to ensure safe use.
Magnesium and Muscle Relaxants
Magnesium itself has muscle-relaxing properties. When taken with muscle relaxants like baclofen or carisoprodol, the effects may be intensified, leading to excessive sedation or weakness.
This can result in respiratory issues or an increased risk of falling. It's important to be cautious when combining magnesium with muscle relaxants and to consult your doctor beforehand.
How to Safely Take Magnesium with Other Medications
Proper Timing and Dosage
To safely take magnesium with other medications, it's best to space out the timing of your supplements. Take magnesium at least 2 hours apart from medications that can interfere with its absorption.
Taking magnesium with food can help improve its absorption and reduce the risk of digestive discomfort.
Always follow the dosage recommendations provided on the supplement label or as advised by your healthcare provider.
Consult Your Healthcare Provider
If you take medications regularly, especially for chronic conditions like high blood pressure or heart disease, consult your healthcare provider before starting magnesium supplementation.
They can help determine the right dosage, form, and timing of magnesium based on your health needs and any current medications you are taking.

Alternatives for Safe Supplementation
If you're concerned about magnesium interactions with medications, your healthcare provider may recommend specific forms of magnesium that are easier on the digestive system, such as magnesium bisglycinate.
This form is well absorbed and less likely to cause digestive issues. Your doctor may also suggest alternative supplementation schedules to ensure safety.
Conclusion
Magnesium is an essential mineral that plays a critical role in your health, but what medications should you not take with magnesium?
Certain medications, including antibiotics, diuretics, PPIs, and blood pressure medications, can interact with magnesium, either affecting absorption or causing dangerous side effects.
To safely incorporate magnesium into your routine, it's important to space out your supplements and consult a healthcare provider about your medications.
Wondering can you take magnesium while pregnant? Or how long does it take for magnesium to start working? Check out our detailed guides for more information!
If you're looking for a premium magnesium bisglycinate product, look no further than VitaCheck Magnesium Bisglycinate 200mg.
This high-quality supplement offers 200mg of bioavailable magnesium per capsule, ensuring optimal absorption and maximum benefits.
With 120 vegetable capsules in each bottle, it supports muscle relaxation, reduces fatigue, and promotes overall well-being.
Perfect for anyone seeking a gentle yet effective way to boost magnesium levels, this product is a must-have for your daily routine.
At Vitamart, we offer a variety of magnesium supplements to help you maintain optimal health. Visit our website today to find the right magnesium supplement for you.
If you want to learn more, check out these articles below:
- Too Much Magnesium Symptoms
- Can You Take Iron and Magnesium Together
- Magnesium L-Threonate Side Effects
- Can Magnesium Cause Headaches?
- Magnesium for Menopause
- Magnesium for Muscles
- Magnesium Heart Palpitations
- Magnesium and Diabetes
- Magnesium Glycinate vs Bisglycinate
- Magnesium Glycinate vs Citrate
- Magnesium vs Magnesium Citrate
- Magnesium Threonate vs Glycinate
- Magnesium Oxide vs Magnesium Glycinate
- Magnesium Gluconate vs Glycinate
- Magnesium Carbonate vs Citrate